期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 17, 期 7, 页码 1624-1633出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8ob02325e
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资金
- Studienstiftung des Deutschen Volkes
Classical steroids are long-known privileged leads in drug discovery. Their rearranged counterparts, though, have so far received less attention, although recent isolation and biological testing programmes have revealed a plethora of molecular entities that are both structurally intriguing, as well as biologically relevant. This review will highlight those natural products, and focus on ergostane-derived seco-and abeo-steroids. Their isolation, structure elucidation, and biological properties are reported. A special emphasis of this review lies in their respective (and typically proposed) biosyntheses, to help guide future bio-inspired synthetic attempts.
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