期刊
NEW JOURNAL OF CHEMISTRY
卷 43, 期 5, 页码 2213-2219出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8nj05766d
关键词
-
资金
- Beijing Municipal Natural Science Foundation [7172036]
In this paper, we developed a silk fibroin nanofiber (SF) hydrogel system complexed with upconversion nanoparticles and nano-graphene oxide (SF/UCNP@NGO) for upconversion luminescence imaging and photothermal therapy. The NaLuF4:Er3+,Yb3+ upconversion nanoparticles were complexed with the nano-graphene oxide composite by a ligand exchange strategy, and then doped into an aqueous SF solution to form a hybrid hydrogel system. In vitro studies demonstrated that the SF/UCNP@NGO hydrogels possessed excellent biocompatibility and were capable of efficiently ablating cancerous cells via the photothermal effect. In vivo antitumor studies further confirmed that the SF/UCNP@NGO hydrogels could present outstanding antitumor efficacy. This work presents a novel hydrogel system, which could not only act as tumor imaging probes, but could also serve as therapy agents.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据