期刊
RSC ADVANCES
卷 9, 期 9, 页码 4812-4815出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8ra10057h
关键词
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资金
- National Natural Science Foundation of China [61605085, 21373114, 21573111, 21603106]
- National Key Basic Research Program of China (973) [2012CB933301]
- Priority Academic Program Development of Jiangsu Higher Education Institutions, PAPD [YX030002]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1148]
- Research Foundation from Nanjing University of Posts and Telecommunications [XK0300915081]
- Qing Lan Project of Jiangsu Province
- NUPT 1311 Project
- Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM)
- Jiangsu Key Laboratory for Biosensors
- Synergetic Innovation Center for Organic Electronics and Information Displays
A photo-switchable and high-contrast bio-imaging indicator 4,4' -(1E, 1'E)-(4,4'-(cyclopentene-1,2-diyl)bis(5-methylthiophene-4,2-diyl))bis(methan-1-yl-1-ylidene)bis(azan-1-yl-1-ylidene)bis(2-(benzo[d]thiazol-2-yl)phenol) (BMBT) has been demonstrated, by integrating photochromophore with excited-state intramolecular proton transfer (ESIPT) moiety. The ability of reversible emission switching enables arbitrarily selective labeling or concealing of cells simply by controlling light irradiation. Besides, when the emission was switched on, BMBT is demonstrated to exhibit unique characteristics of aggregation induced emission (AIE), providing a high on-off ratio for favorable bio-imaging. Thus, the non-labeling and easily-controlled selective imaging, as well as good biocompatibility indicates BMBT to be a favorable cell probe with great potentials for functional bio-imaging fluorophore.
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