期刊
MEDICINE
卷 96, 期 30, 页码 -出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MD.0000000000007612
关键词
children; genetic susceptibility; H. pylori infection
The aim of our study was to investigate the impact of interleukin (IL)-6 190C/T, IL-6 174G/C, IL-6 572G/C, tumor necrosis factoralpha (TNF-alpha) 308G/A, and angiotensin-converting enzyme (ACE) I/D gene polymorphisms on Helicobacter pylori (H. pylori) infection in children. A cross-sectional study was performed on 126 children (57 children with H. pylori infection and 69 children without H. pylori infection) aged between 3 and 18 years presenting to a Pediatrics Tertiary Hospital from Romania. Children were assessed clinically, endoscopically, histopathologically, and genetically. In our study, we found that the presence of the CT and CT+ TT genotypes of IL-6 190C/T (P<.002 and P=.04), allele G of IL-6 572 G/C polymorphism (P=.01), genotypes GA and AA of TNF-alpha 308G/A polymorphism (P=.04, P=.01), and genotype II of ACE I/D polymorphism (P=.02) were associated with H. pylori infection, while the CC genotype of IL-6 174G/C polymorphism was scarcely encountered in children with H. pylori infection [P=.02, odds ratio (OR)=0.06; 95% confidence interval (95% CI): 0.003-0.128]. Taking under consideration the 4 variant genotypes (IL-6 572G/C, IL-6 190C/T, TNF-alpha 308G/A, and ACE I/D), we noticed a 2 times higher incidence of H. pylori infection (OR=6.34; 95% CI: 2.15-25.8). We may consider that the IL-6 190C/T, IL-6 174G/C, IL-6 572G/C, TNF-alpha 308G/A, and ACE I/D gene polymorphisms may increase the children's susceptibility for acquiring H. pylori infection; therefore, they may contribute to the pathogenesis of H. pylori gastritis.
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