期刊
CELL CHEMICAL BIOLOGY
卷 26, 期 2, 页码 156-177出版社
CELL PRESS
DOI: 10.1016/j.chembiol.2018.10.022
关键词
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The ubiquitin/proteasome system is a primary conduit for selective intracellular protein degradation. Since its discovery over 30 years ago, this highly regulated system continues to be an active research area for drug discovery that is exemplified by several approved drugs. Here we review compounds in preclinical testing, clinical trials, and approved drugs, with the aim of highlighting innovative discoveries and breakthrough therapies that target the ubiquitin system.
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