期刊
MEDICINE
卷 96, 期 42, 页码 -出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MD.0000000000008184
关键词
Gorham disease; mandible; massive osteolysis; prognosis
资金
- National Natural Science Foundation of China [81602377]
Rationale:Gorham-Stout disease (GSD) is characterized by aggressive bone resorption, proliferation of vascular or lymphatic vessels, and soft-tissue swelling. Bones that initially appear normal start to resorb, partially or completely. However, the etiology of GSD is unknown.Patient concerns:A 29-year-old man with a chief complaint of toothache and mobility in the lower right mandible for the previous 1 year.Diagnoses:Gorham-Stout disease (GSD).Interventions:The RANK-ligand inhibitor denosumab was suggested to use to inhibit the development of osteoclasts and slow mandibular resorption. In addition, we proposed resection of the remaining mandible and reconstruction via vascularized bone graft, after resorption of the mandible had become stationary.Outcomes:Regular follow-ups were advised to this patient to monitor the stability of bone resorption prior to any surgical intervention.Lessons:We strongly recommend that every attempt should be made for early diagnosis and prompt effective medical and surgical management. The failure to do so results in further complications and poor prognosis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据