期刊
FRONTIERS IN IMMUNOLOGY
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2019.00346
关键词
neutrophil; immune mediated disease; therapeutic opportunities; granulopoiesis; neutrophil migration; CD177; autoimmune; therapeutic targeting
类别
资金
- Boehringer Ingelheim Fonds
- German Academic Scholarship Foundation (Studienstiftung)
- JBC Microgrant
- NIH [R01 AR065538, R01 AR073201, P30 AR070253]
- Fundacion Bechara
- Arbuckle Family Fund for Arthritis Research
Neutrophils are versatile innate effector cells essential for immune defense but also responsible for pathologic inflammation. This dual role complicates therapeutic targeting. However, neither neutrophils themselves nor the mechanisms they employ in different forms of immune responses are homogeneous, offering possibilities for selective intervention. Here we review heterogeneity within the neutrophil population as well as in the pathways mediating neutrophil recruitment to inflamed tissues with a view to outlining opportunities for therapeutic manipulation in inflammatory disease.
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