期刊
EFSA JOURNAL
卷 17, 期 2, 页码 -出版社
EUROPEAN FOOD SAFETY AUTHORITY-EFSA
DOI: 10.2903/j.efsa.2019.5601
关键词
nutritional additive; amino acid; L-tryptophan safety; efficacy; genetically modified microorganism
Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on L-tryptophan produced by fermentation with a genetically modified strain of Escherichia coli CGMCC 7.248 when used as a nutritional additive in feed and water for drinking for all animal species and categories. The production strain E. coli CGMCC 7.248 and its recombinant DNA were not detected in the final product. The product L-tryptophan, manufactured by fermentation with E. coli CGMCC 7.248, does not give rise to any safety concern with regard to the genetic modification of the production strain. L-Tryptophan produced by E. coli CGMCC 7.248 is safe for non-ruminant target species. The use of unprotected L-tryptophan in ruminant feed should be avoided. L-Tryptophan produced by fermentation by E. coli CGMCC 7.248 is safe for the consumer. The level of endotoxins present in the product and its dusting potential indicate an inhalation risk for the user. L-Tryptophan produced by E. coli CGMCC 7.248 is not a skin or eye irritant but it is a dermal sensitiser. The use of L-tryptophan produced by E. coli CGMCC 7.248 in animal nutrition does not pose a risk to the environment. The product under assessment is regarded as an effective source of the amino acid L-tryptophan for all non-ruminant species. For the supplemental L-tryptophan to be as efficacious in ruminants as in non-ruminant species, it requires protection against degradation in the rumen. (C) 2019 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority.
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