期刊
MEDICINE
卷 96, 期 30, 页码 -出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MD.0000000000007647
关键词
adenocarcinoma of esophagogastric junction; neutrophil-lymphocyte ratio; overall survival; platelet-lymphocyte ratio; prognostic nutritional index
资金
- National Natural Science Foundation of China [81572350]
Background:Immune and nutritional status of patients have been reported to predict postoperative complications, recurrence, and prognosis of patients with cancer. Therefore, this retrospective study aimed to explore the prognostic value of preoperative inflammation-based prognostic scores [neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR)] and nutritional status [prognostic nutritional index (PNI), body mass index (BMI), hemoglobin, albumin, and prealbumin] for overall survival (OS) in adenocarcinoma of esophagogastric junction (AEG) patients. Methods:A total of 355 patients diagnosed with Siewert type II/III AEG and underwent surgery between October 2010 and December 2011 were followed up until October 2016. Receiver operating characteristic (ROC) curve analysis was used to determine the cutoff values of NLR, PLR, and PNI. Kaplan-Meier curves and Cox regression analyses were used to calculate the OS characteristics. Results:The ideal cutoff values for predicting OS were 3.5 for NLR, 171 for PLR, and 51.3 for PNI according to the ROC curve. The patients with hemoglobin <120g/L (P=.001), prealbumin <180mg/L (P=.000), PNI <51.3 (P=.010), NLR >3.5 (P=.000), PLR >171 (P=.006), and low BMI group (P=.000) had shorter OS. And multivariate survival analysis using the Cox proportional hazards model showed that the tumor-node-metastasis stage, BMI, NLR, and prealbumin levels were independent risk factors for the OS. Conclusion:Our study demonstrated that preoperative prealbumin, BMI, and NLR were independent prognostic factors of AEG patients.
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