期刊
SCIENTIFIC REPORTS
卷 9, 期 -, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41598-019-40247-9
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资金
- Finnish Academy of Science and Letters, Academy of Finland [304458]
- Aarne Koskelo Foundation
- Tampere University of Technology graduate school grant
- University of Tampere graduate school grant
- Academy of Finland (AKA) [304458, 304458] Funding Source: Academy of Finland (AKA)
We study complex scaling properties of RR and QT intervals of electrocardiograms (ECGs) with their equivalences at the cellular level, that is, inter-beat intervals (IBI) and field potential durations (FPD) of spontaneously beating human-induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) aggregates. Our detrended fluctuation analysis and Poincare plots reveal remarkable similarities between the ECG and hiPSC-CM data. In particular, no statistically significant difference was found in the short-and long-term scaling exponents alpha(1) and alpha(2) of RR and QT intervals and their cellular equivalences. Previously unknown scaling properties of FPDs of hiPSC-CM aggregates reveal that the increasing scaling exponent of QT intervals as a function of the time scale, is an intrinsic feature at the cellular level.
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