期刊
CRYSTENGCOMM
卷 21, 期 10, 页码 1617-1625出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8ce01848k
关键词
-
资金
- National Natural Science Foundation of China [NNSFC 21676179, 91634117]
- Major National Science and Technology Project [2017ZX09101001]
In this research, the crystal structure of antidiabetic drug gliquidone (GQD) is analysed and multicomponent crystals such as piperazine (PPZ) salt and eutectics are designed and synthesized based on its structural features. Three polymorphs of the salt are obtained together with five solvates. Fortunately, four single crystals of the salts are determined for the first time. The results reveal that the high hydrogen bond-forming ability of PPZ plays a vital role in breaking the original packing of GQD and resulting in salts instead of eutectics. Finally, comprehensive characterization of the salt polymorphs is performed and the result shows that the powder properties and powder dissolution are enhanced by the salt formation compared with the parent form.
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