期刊
ACS APPLIED BIO MATERIALS
卷 2, 期 3, 页码 975-980出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.8b00783
关键词
interpenetrating networks; neural stem cells; astrocytes; microglia
资金
- Alzheimer's Association [AARGD-17-531470]
- Alzheimer's Texas [AARGD-17-531470]
- Trinity University Murchison research fellowship
- Trinity University start up fund
This work describes for the first time the fabrication and characterization of multicomponent interpenetrating networks composed of collagen I, hyaluronic acid, and poly(ethylene glycol) diacrylate for the 3D culture of human neural stem cells, astrocytes, and microglia. The chemical composition of the scaffolds can be modulated while maintaining values of complex moduli within the range of the mechanical performance of brain tissue (similar to 6.9 kPa) and having cell viability exceeding 84%. The developed scaffolds are a promising new family of biomaterials that can potentially serve as 3D in vitro models for studying the physiology and physiopathology of the central nervous system.
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