期刊
ACS APPLIED BIO MATERIALS
卷 2, 期 3, 页码 952-969出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.8b00637
关键词
electrospinning; wound healing; bioactivity; mechanical properties; antibacterial performance
资金
- National Plan for Science, Technology and Innovation (MAARIFAH) - King Abdulaziz City for Science and Technology -the Kingdom of Saudi Arabia [12-MED3096-3]
- Scientific WAQF Fund at King Abdulaziz University (KAU), Jeddah [17/1436]
- Northeastern University (Boston, MA, USA) Seed Grant/Proof of Concept Tier 1 Research Grant
- Department of Chemical Engineering
- Burroughs Wellcome Fund (BWF)
- Thomas Jefferson/Face foundations
Electrospinning is a versatile technique used to create native tissue-like fibrous scaffolds. Recently, it has gained a large amount of attention for generation of bioactive dressing materials suitable for treatment of both chronic and acute wounds. In this Review, we focus on the latest advances made in the application of electrospun scaffolds for bioactive wound healing. We first provide a brief overview of the wound healing process and electrospinning approaches. We then discuss fabrication of scaffolds made from natural and synthetic polymers via electrospinning for effective wound treatment and management. Natural polymers used for wound healing included in our Review cover protein based polymers such as collagen, gelatin, and silk and polysaccharide based polymers such as chitosan, hyaluronic acid, and alginate. In addition, we discuss aliphatic polyesters, super hydrophilic polymers, and polyurethanes as some of the most commonly used synthetic polymers for wound healing and wound dressing applications. Next, we review multifunctional and smart scaffolds developed by electrospinning based approaches. We place an emphasis on how flexibility of the electrospinning process enables production of advanced scaffolds such as core-shell fibrous scaffolds, multilayer scaffolds, and surface modified scaffolds. Taken together, it is clear that electrospinning is an emerging technology that provides a unique opportunity for engineering more effective wound dressing, management, and care products.
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