期刊
MEDICINAL RESEARCH REVIEWS
卷 38, 期 4, 页码 1159-1187出版社
WILEY
DOI: 10.1002/med.21461
关键词
age-related diseases; nitric oxide donors; nitrones; nitroxides; nitroxyl donors; spin traps
资金
- Foundation for Science and Technology (FCT)
- FEDER/COMPETE [UID/QUI/00081/2013, NORTE-01-0145-FEDER-000028]
- FCT [SFRH/BD/88773/2012, SFRH/BD/99189/2013, SFRH/BD/98519/2013, SFRH/BPD/74491/2010, SFRH/BPD/114945/2016]
- FEDER/COMPETE funds
- COST action [CA15135]
The biological effects attributed to nitric oxide ((NO)-N-center dot) and nitroxyl (HNO) have been extensively studied, propelling their array of putative clinical applications beyond cardiovascular disorders toward other age-related diseases, like cancer and neurodegenerative diseases. In this context, the unique properties and reactivity of the N-O bond enabled the development of several classes of compounds with potential clinical interest, among which (NO)-N-center dot and HNO donors, nitrones, and nitroxides are of particular importance. Although primarily studied for their application as cardioprotective agents and/or molecular probes for radical detection, continuous efforts have unveiled a wide range of pharmacological activities and, ultimately, therapeutic applications. These efforts are of particular significance for diseases in which oxidative stress plays a key pathogenic role, as shown by a growing volume of in vitro and in vivo preclinical data. Although in its early stages, these efforts may provide valuable guidelines for the development of new and effective N-O-based drugs for age-related disorders. In this report, we review recent advances in the chemistry of NO and HNO donors, nitrones, and nitroxides and discuss its pharmacological significance and potential therapeutic application.
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