期刊
MEDICINAL RESEARCH REVIEWS
卷 37, 期 6, 页码 1373-1428出版社
WILEY
DOI: 10.1002/med.21437
关键词
histone deacetylase inhibitors; hydroxamic acids; benzamides; cyclic peptides; epigenetics
Histone deacetylases (HDACs) play a crucial role in the remodeling of chromatin, and are involved in the epigenetic regulation of gene expression. In the last decade, inhibition of HDACs came out as a target for specific epigenetic changes associated with cancer and other diseases. Until now, more than 20 HDAC inhibitors (HDACIs) have entered clinical studies, and some of them (e.g., vorinostat, romidepsin) have been approved for the treatment of cutaneous T-cell lymphoma. This review provides an overview of current knowledge, progress, and molecular mechanisms of HDACIs, covering a period from 2011 until 2015. (C) 2017 Wiley Periodicals, Inc.
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