期刊
MEDICINAL RESEARCH REVIEWS
卷 37, 期 6, 页码 1275-1298出版社
WILEY
DOI: 10.1002/med.21459
关键词
antibiotics; autophagy; cancer; cancer stem cells; mitochondria; mitochondrial dysfunction; mitophagy
资金
- Instituto de Salud Carlos III [PI12/01104, PI15/01262]
- Marie Curie INCOMED senior fellowship [GA267128]
Mitochondrial dysfunction (MDF) has been identified as an important factor in various diseases ranging from neurological disorders, to diseases of the cardiovascular system and metabolic syndromes. MDF was also found in cancer as well as in cancer predisposition syndromes with defective DNA damage response (DDR) machinery. Moreover, a recent highlight arises from the detection of MDF in eukaryotic cells upon treatment with antibiotics. In this review, we focus on recent studies of MDF in pathological conditions with a particular emphasis on the effects of various classes of antibiotics on mitochondria. Special attention is given to the role of autophagy/mitophagy in MDF and repurposing antibiotics as anticancer drugs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据