期刊
MEDICINAL CHEMISTRY RESEARCH
卷 26, 期 4, 页码 819-829出版社
SPRINGER BIRKHAUSER
DOI: 10.1007/s00044-017-1781-5
关键词
EGFR kinase enzyme; Non-small cell lung cancer; Molecular docking; Antitumor activity; NCI
Cancer, which is considered to be the world's most serious illness cause 8.2 million deaths and this rate may double by 2030. We herein report a new series of 3-(2( p-substituted)-2-((5-phenyl-1,3,4-thiadiazol-2-yl) imino)-2( p-substituted) ethylidene) indolin-2-one (15-19) and 5-substituted- 5'-substituted phenyl-2', 4'-dihydrospiro[indoline-3,3'- pyrazol]-2-one derivatives (20-24) as potent anticancer agents. These compounds were evaluated for in vitro antitumor activity against the National Cancer Institute panel of 60 cancer cell lines. Among all the synthesized compounds, two compounds 15 and 16 showed remarkable antitumor activity with GI(50) (MG-MID) values of 0.65 & 0.72 mu M, respectively against Non-small cell lung cancer. To gain insight for mode of binding with Epidermal Growth Factor Receptor kinase enzyme, these compounds were further subjected to docking studies.
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