期刊
ANTIOXIDANTS
卷 8, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/antiox8020048
关键词
hydrogen sulfide; persulfide; hydropersulfide; reactive oxygen species; sulfiyl radical
资金
- Comision Sectorial de Investigacion Cientifica (CSIC) from Universidad de la Republica [GRUPOS_I+D_2014_C632-348, I+D_2016_541]
- Agencia Nacional de Investigacion e Innovacion (ANII) [FCE_1_2017_1_136043]
- Fondo Vaz Ferreira, Ministerio de Educacion y Cultura [I/FVF2017/069]
- Comision Academica de Posgrado (CAP) from Universidad de la Republica
- PEDECIBA (Uruguay)
Hydrogen sulfide (H2S/HS-) can be formed in mammalian tissues and exert physiological effects. It can react with metal centers and oxidized thiol products such as disulfides (RSSR) and sulfenic acids (RSOH). Reactions with oxidized thiol products form persulfides (RSSH/RSS-). Persulfides have been proposed to transduce the signaling effects of H2S through the modification of critical cysteines. They are more nucleophilic and acidic than thiols and, contrary to thiols, also possess electrophilic character. In this review, we summarize the biochemistry of hydrogen sulfide and persulfides, focusing on redox aspects. We describe biologically relevant one- and two-electron oxidants and their reactions with H2S and persulfides, as well as the fates of the oxidation products. The biological implications are discussed.
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