期刊
ACS OMEGA
卷 4, 期 1, 页码 140-145出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.8b02970
关键词
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资金
- Millipore, Inc
- Trask Fund of the Purdue Research Foundation
- Leidos
- Purdue Univ. Center for Cancer Research, NIH [P30 CA023168]
Isotopic variants of Rhodamine 6G (R6G) have previously been used as a method of multiplexed detection for Surface Enhanced Raman Spectroscopy (SERS), including protein detection and quantification. Challenges exist, however, with producing long-term stable SERS signals with exposure to silver or gold metal surfaces without the use of additional protective coatings of nanomaterials. Here, novel rhodamine dimers and trimers have been created that demonstrate a higher avidity for metal nanoparticles and induce aggregation to create plasmonic hotspots as indicated by enhanced Raman scattering in situ. These aggregates can be formed in a colloid, on surfaces, or membrane substrates such as poly(vinylidene fluoride) for applications in biosciences. The integrity of the materials and Raman signals are maintained for months of time on different substrates. These dye materials should provide avenues for simplified in situ generation of sensors for Raman-based assays especially in settings requiring highly robust performance.
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