期刊
SCIENTIFIC REPORTS
卷 9, 期 -, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41598-019-40629-z
关键词
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资金
- Ministry of Science and Technology, Taiwan [MOST-106-2311-B-182-005, MOST-107-2311-B-182-001]
- Chang Gung Memorial Hospital, Taiwan [CIRPD3B0013]
- Molecular Medicine Research Center, Chang Gung University from The Featured Areas Research Center Program within Ministry of Education (MOE) in Taiwan
Because of innumerable cancer sequencing projects, abundant transcriptome expression profiles together with survival data are available from the same patients. Although some expression signatures for prognosis or pathologic staging have been identified from these data, systematically discovering such kind of expression signatures remains a challenge. To address this, we developed TACCO (Transcriptome Alterations in CanCer Omnibus), a database for identifying differentially expressed genes and altered pathways in cancer. TACCO also reveals miRNA cooperative regulations and supports construction of models for prognosis. The resulting signatures have great potential for patient stratification and treatment decision-making in future clinical applications. TACCO is freely available at http://tacco.life.nctu.edu.tw/.
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