期刊
JCI INSIGHT
卷 4, 期 5, 页码 -出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/jci.insight.125278
关键词
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资金
- Rheumatology Research Foundation
- Innovative Research Award from Rheumatology Research Foundation
- Fundacion Bechara
- Arbuckle Family Fund for Arthritis Research
- NIH [R01 AR065538, R01 AR073201, P30 AR070253]
Inflammatory arthritis encompasses a set of common diseases characterized by immune-mediated attack on joint tissues. Most but not all affected patients manifest circulating autoantibodies. Decades of study in human and animal arthritis have identified key roles for autoantibodies in immune complexes and through direct modulation of articular biology. However, joint inflammation can arise because of pathogenic T cells and other pathways that are antibody-independent. Here we review the evidence for these parallel tracks, in animal models and in humans, to explore the range of mechanisms engaged in the pathophysiology of arthritis and to highlight opportunities for targeted therapeutic intervention.
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