期刊
MEDICAL ONCOLOGY
卷 34, 期 5, 页码 -出版社
HUMANA PRESS INC
DOI: 10.1007/s12032-017-0959-5
关键词
Long noncoding RNAs; LincRNa; p21; Genes expression; Cancer
类别
资金
- National Natural Science Foundation of China [81273116]
- Science Foundation of Guangdong Medical University [M2013004]
In view of the rapid development of gene chips and high-throughput sequencing technology, noncoding RNAs (ncRNas) form a high percentage of the mammalian genome. Two major subgroups of ncRNAs that have been identified are the long ncRNAs (lncRNas) and the microRNAs. A number of studies in the past few years have showed crucial functions for lncRNas in cancer. LincRNa-p21 as a p53-dependent transcriptional target gene and a potential diagnostic marker is involved in proliferation, cell cycle, metabolism and reprogramming. In addition, more researches revealed that lincRNa-p21 is associated with cancer progression and contributed to the treatment and prognosis of cancer. In this review, we briefly summarize the function and molecular mechanisms of lincRNa-p21 in cancer and its regulation for the genes expression.
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