期刊
MEDICAL MYCOLOGY
卷 56, 期 6, 页码 778-781出版社
OXFORD UNIV PRESS
DOI: 10.1093/mmy/myx097
关键词
beta-D-glucan; Pneumocystis pneumonia; Dynamiker Fungus Assay
The Dynamiker (R) Fungus (1-3)-beta-D-Glucan Assay (D-BDG) has recently become available in the Western Hemisphere for the diagnosis of invasive fungal disease (IFD). Evaluations of its performance for Pneumocystis pneumonia (PcP) are limited. A retrospective evaluation of D-BDG diagnosis of PcP was performed (23 PcP cases and 23 controls). Sensitivity and specificity were 87% and 70%, respectively, reducing the positivity threshold to 45 pg/ml increased sensitivity (96%), whereas a threshold of 300 pg/ml increased specificity (96%). The performance of D-BDG for the detection of PcP is comparable to other IFD, but sensitivity is below that required to confidently exclude PcP.
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