期刊
MEDICAL MYCOLOGY
卷 56, 期 4, 页码 501-505出版社
OXFORD UNIV PRESS
DOI: 10.1093/mmy/myx067
关键词
Aspergillus; cryptic species; amphotericin B; triazole susceptibility; multicenter study
资金
- Research of Korea Centers for Disease Control and Prevention [2015E4400100]
- Basic Science Research Program through the National Research Foundation of Korea (NRF)
- Ministry of Education [NRF-2016R1A2B4008181, NRF-2016R1C1B1009746]
We investigated the in vitro antifungal susceptibilities of cryptic Aspergillus species from nine Korean hospitals. Based on the CLSI epidemiological cutoff values, resistance rates to amphotericin B, itraconazole, voriconazole, posaconazole and caspofungin were as follows: A. awamori (34 isolates; all 0%), A. tubingensis (22; 0%, 4.5%, 0%, 0%, and 0%, respectively), A. sydowii (16; 0%, 6.3%, 0%, 0%, and 6.3%), A. lentulus (2; 50%, 0%, 100%, 50%, and 0%), and A. tamarii (2; all 0%). A. calidoustus (one isolate) showed resistance to multiple drugs. Thus, cryptic species identification can be mandatory for clinically important Aspergillus isolates, with their susceptibility data.
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