期刊
MEDICAL MYCOLOGY
卷 56, 期 3, 页码 374-377出版社
OXFORD UNIV PRESS
DOI: 10.1093/mmy/myx045
关键词
adhesins; Paracoccidioides brasiliensis; Galleria mellonella; mice; fungal-host cell interaction; virulence factors
资金
- Fundacao de Apoio a Pesquisa do Estado de Sao Paulo-FAPESP [2013/10917-9, 2014/10446-9, 2015/03700-9, 2015/14023-8, 2016/17048-4]
- Programa de Apoio ao Desenvolvimento Cientifico da Faculdade de Ciencias Farmaceuticas da UNESP (PADC/FCF)
Paracoccidioidomycosis (PCM) is a fungal disease restricted to Latin countries, and its etiologic agents derive from the Paracoccidioides genus. Attenuation or loss of virulence in Paracoccidioides spp. following successive subculturing has been described. However, virulence can be recovered by passage in mammalian host. In this study, the recovery of adhesion of P. brasiliensis through passage in mice was compared to that in the insect Galleria mellonella. Analysis of in vitro fungal-host cell interaction, gene expression of adhesins, and analysis of the survival curves revealed that Galleria mellonella is useful for the reactivation of P. brasiliensis adhesion.
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