期刊
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
卷 122, 期 -, 页码 54-60出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2015.06.030
关键词
Nitenpyram; Antioxidant system; GST; ROS; MDA; Comet assay
资金
- National Natural Science Foundation of China [21277083, 21377075, 41071164, 41001152]
- Specialized Research Fund for the Doctoral Program of Higher Education [20113702110007]
- Natural Science Foundation of Shandong [ZR2013DQ007]
Nitenpyram is one of the most commonly used neonicotinoid pesticide worldwide and was found to be toxic to non-target aquatic organisms. Therefore, the purpose of this study was to investigate the oxidative stress, changes in the detoxifying system and DNA damage in zebrafish induced by nitenpyram. In, the present study, zebrafish (Danio rerio) were exposed to four concentrations (0.6, 1.2, 2.5, and 5.0 mg L-1) for 28 d and then sampled in triplicate on days 7, 14, 21 and 28. Superoxide dismutase (SOD) and catalase (CAT) activities were dramatically inhibited at most exposure times compared with the control group, except SOD at low concentration (0.6 mg L-1) of nitenpyram and CAT on day 21. This difference is due to the excess reactive oxygen species (ROS) produced and increased malondialdehyde (MDA) content in zebrafish livers. The activity of glutathione S-transferase (GST) increased in in the treatment groups at a higher concentration compared with the control group. We found that nitenpyram exposure could affect the antioxidant enzymes and DNA damage in the exposed zebrafish livers. Additionally, the changes in the antioxidant enzyme activities could be an adaptive response protecting against the toxicity induced by nitenpyram. (C) 2015 Published by Elsevier Inc.
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