期刊
MEDICAL ENGINEERING & PHYSICS
卷 43, 期 -, 页码 97-102出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.medengphy.2017.01.018
关键词
Spasticity; Electrical impedance myography (EIM); Botulinum Toxin A (BoNT-A)
资金
- National Institutes of Health of the U.S. Department of Health and Human Services [R01NS080839]
- Memorial Hermann Foundation
This study aimed to investigate the immediate impacts of Botulinum Toxin A (BoNT-A) injections on the inherent electrical properties of spastic muscles using a newly developed electrical impedance myography (EIM) technique. Impedance measures were performed before and after a BoNT-A injection in biceps brachii muscles of 14 subjects with spasticity. Three major impedance variables, resistance (R), reactance (X) and phase angle (theta) were obtained from three different configurations, and were evaluated using the conventional EIM frequency at 50 kHz as well as multiple frequency analysis. Statistical analysis demonstrated a significant decrease of resistance in the injected muscles (Multiple frequency: R-pre = 25.17 +/- 1.94 Ohm, R-post = 23.65 +/- 1.63 Ohm, p < 0.05; 50 kHz: R-pre = 29.06 +/- 2.16 Ohm, R-post = 27.7 +/- 1.89 Ohm, p < 0.05). Despite this decrease, there were no substantial changes in the reactance, phase angle, or anisotropy features after a BoNT-A injection. The significant changes of muscle resistance were most likely associated with the liquid injection of the BoNT-A-saline solution rather than the immediate toxin effects on the muscle. This study demonstrated high sensitivity of the EIM technique in the detection of alterations to muscle composition. (C) 2017 IPEM. Published by Elsevier Ltd. All rights reserved.
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