期刊
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
卷 111, 期 -, 页码 9-22出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2014.09.021
关键词
OECD tests; Biodegradation; Persistence; Chemical risk assessment; Microbial ecology; Omics
资金
- Unilever
- Cefic LRi
- Engineering and Physical Sciences Research Council
- AstraZeneca
- Biotechnology and Biological Sciences Research Council
- EPSRC [EP/I025782/1] Funding Source: UKRI
- NERC [NE/J014168/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/I025782/1] Funding Source: researchfish
- Natural Environment Research Council [NE/J014168/1] Funding Source: researchfish
Society's reliance upon chemicals over the last few decades has led to their increased production, application and release into the environment. Determination of chemical persistence is crucial for risk assessment and management of chemicals. Current established OECD biodegradation guidelines enable testing of chemicals under laboratory conditions but with an incomplete consideration of factors that can impact on chemical persistence in the environment. The suite of OECD biodegradation tests do not characterise microbial inoculum and often provide little insight into pathways of degradation. The present review considers limitations with the current OECD biodegradation tests and highlights novel scientific approaches to chemical fate studies. We demonstrate how the incorporation of molecular microbial ecology methods (i.e., 'omics') may improve the underlying mechanistic understanding of biodegradation processes, and enable better extrapolation of data from laboratory based test systems to the relevant environment, which would potentially improve chemical risk assessment and decision making. We outline future challenges for relevant stakeholders to modernise OECD biodegradation tests and put the 'bio' back into biodegradation. (C) 2014 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据