期刊
CHEMICAL SCIENCE
卷 10, 期 10, 页码 3118-3122出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8sc05737k
关键词
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资金
- National Natural Science Foundation of China [21522207, 21702184, 21772175]
- Natural Science and Engineering Research Council (NSERC)
- University of Toronto
- Alphora Inc.
- province of Ontario for a Graduate Scholarship (OGS)
A palladium-catalyzed dearomative arylborylation of indoles is reported, which provides straightforward access to structurally diverse indolines bearing vicinal tetrasubstituted and borylated trisubstituted stereocenters in moderate to good yields with excellent diastereoselectivities. By using a BINOL-based chiral phosphoramidite ligand and an sp(2)-sp(3) mixed-boron reagent, an enantioselective dearomative arylborylation was achieved and chiral boron-containing products were accessed in up to 94% ee. Synthetic tranformations of the resulting organoborons were conducted to afford a number of unique indoline derivatives.
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