期刊
MECHANISMS OF DEVELOPMENT
卷 144, 期 -, 页码 92-101出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mod.2016.11.003
关键词
Muscle; Tension; Force; Biomechanics; Sarcomere; Myofibrillogenesis; Self-organization; Integrin; Titin
资金
- European Research Council under the European Union's Seventh Framework Programme [310939]
- EMBO Young Investigator Program
- Max Planck Society
- Centre National de la Recherche Scientifique (CNRS)
- Boehringer Ingelheim Fonds
- European Research Council (ERC) [310939] Funding Source: European Research Council (ERC)
Muscles are the major force producing tissue in the human body. While certain muscle types specialize in producing maximum forces, others are very enduring. An extreme example is the heart, which continuously beats for the entire life. Despite being specialized, all body muscles share similar contractile mini-machines called sarcomeres that are organized into regular higher order structures called myofibrils. The major sarcomeric components and their organizational principles are conserved throughout most of the animal kingdom. In this review, we discuss recent progress in the understanding of myofibril and sarcomere development largely obtained from in vivo models. We focus on the role of mechanical forces during muscle and myofibril development and propose a tension driven self-organization mechanism for myofibril formation. We discuss recent technological advances that allow quantification of forces across tissues or molecules in vitro and in vivo. Although their application towards muscle development is still in its infancy, these technologies are likely to provide fundamental new insights into the mechanobiology of muscle and myofibril development in the near future. (C) 2016 The Authors. Published by Elsevier Ireland Ltd.
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