期刊
MECHANISMS OF AGEING AND DEVELOPMENT
卷 161, 期 -, 页码 211-224出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2016.07.006
关键词
Apoptosis; Autophagy; Cell cycle; DNA damage; Yeast
资金
- Malta Council for Science & Technology through the R&I Technology Development Programme [RI-2015-001]
Regulation of the cell cycle and apoptosis are two eukaryotic processes required to ensure maintenance of genomic integrity, especially in response to DNA damage. The ease with which yeast, amongst other eukaryotes, can switch from cellular proliferation to cell death may be the result of a common set of biochemical factors which play dual roles depending on the cell's physiological state. A wide variety of homologues are shared between different yeasts and metazoans and this conservation confirms their importance. This review gives an overview of key molecular players involved in yeast cell-cycle regulation, and those involved in mechanisms which are induced by cell-cycle dysregulation. One such mechanism is autophagy which, depending on the severity and type of DNA damage, may either contribute to the cell's survival or death. Cell-cycle dysregulation due to checkpoint deficiency leads to mitotic catastrophe which in turn leads to programmed cell death. Molecular players implicated in the yeast apoptotic pathway were shown to play important roles in the cell cycle. These include the metacaspase Ycal p, the caspase-like protein Esplp, the cohesin subunit Mcdl p, as well as the inhibitor of apoptosis protein Birl p. The roles of these molecular players are discussed. (C) 2016 The Author(s). Published by Elsevier Ireland Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据