期刊
MATRIX BIOLOGY
卷 75-76, 期 -, 页码 27-42出版社
ELSEVIER
DOI: 10.1016/j.matbio.2017.10.004
关键词
Extracellular matrix; Senescence; Age-related disease; Cancer; Tissue repair; Fibrosis
资金
- EU Horizon 2020 project RISE-2014 [645756]
Normal cells after a defined number of successive divisions or after exposure to genotoxic stresses are becoming senescent, characterized by a permanent growth arrest. In addition, they secrete increased levels of pro-inflammatory and catabolic mediators, collectively termed senescence-associated secretory phenotype. Furthermore, senescent cells exhibit an altered expression and organization of many extracellular matrix components, leading to specific remodeling of their microenvironment. In this review we present the current knowledge on extracellular matrix alterations associated with cellular senescence and critically discuss certain characteristic examples, highlighting the ambiguous role of senescent cells in the homeostasis of various tissues under both normal and pathologic conditions. (C) 2017 Elsevier B.V. All rights reserved.
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