期刊
ENDOCRINOLOGY AND METABOLISM
卷 34, 期 1, 页码 39-46出版社
KOREAN ENDOCRINE SOC
DOI: 10.3803/EnM.2019.34.1.39
关键词
Mitochondria; Fatty liver; Metabolism; Obesity; Insulin resistance
资金
- Korean Endocrine Society of New Faculty Research Award
- Chungnam National University Hospital Research Fund
- Basic Science Research Program, National Research Foundation, Ministry of Science and ICT, Future Planning, Korea [NRF-2018R1C1B6004439]
The signaling network of the mitochondrial unfolded protein response (UPRmt) and mitohormesis is a retrograde signaling pathway through which mitochondria-to-nucleus communication occurs in organisms. Recently, it has been shown that the UPRmt is closely associated with metabolic disorders and conditions involving insulin resistance, such as alcoholic and non-alcoholic fatty liver and fibrotic liver disease. Scientific efforts to understand the UPRmt and mitohormesis, as well as to establish the mitochondrial proteome, have established the importance of mitochondrial quality control in the development and progression of metabolic liver diseases, including non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). In this review, we integrate and discuss the recent data from the literature on the UPRmt and mitohormesis in metabolic liver diseases, including NAFLD/NASH and fibrosis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据