期刊
BIOMARKER RESEARCH
卷 7, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s40364-019-0159-x
关键词
Exosomes; Mesenchymal stem cell; Clinical trial; Disease
资金
- CAMS Innovation Fund for Medical Sciences [2017-I2M-3-007]
- Beijing Key Laboratory of New Drug Development and Clinical Trial of Stem Cell Therapy [BZ0381]
- Qingdao University newly introduced talent research [41117010251]
Mesenchymal stem/stromal cells (MSCs) have been demonstrated to hold great potential for the treatment of several diseases. Their therapeutic effects are largely mediated by paracrine factors including exosomes, which are nanometer-sized membrane-bound vesicles with functions as mediators of cell-cell communication. MSC-derived exosomes contain cytokines and growth factors, signaling lipids, mRNAs, and regulatory miRNAs. Increasing evidence suggests that MSC-derived exosomes might represent a novel cell-free therapy with compelling advantages over parent MSCs such as no risk of tumor formation and lower immunogenicity. This paper reviews the characteristics of MSC exosomes and their fate after in vivo administration, and highlights the therapeutic potential of MSC-derived exosomes in liver, kidney, cardiovascular and neurological disease. Particularly, we summarize the recent clinical trials performed to evaluate the safety and efficacy of MSC exosomes. Overall, this paper provides a general overview of MSC-exosomes as a new cell-free therapeutic paradigm.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据