期刊
NANOSCALE
卷 11, 期 11, 页码 5014-5020出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8nr09801h
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资金
- National Natural Science Foundation of China [81602610, 21874103]
- National Natural Science Foundation of Jiangsu Province, China [BK20160381]
- 1000 Young Talent Program of China
Glutathione (GSH) plays a vital role in biological systems and is associated with human pathology. The engineering of semiconductor quantum dots (QDs) as fluorescent probes for GSH sensing and bioimaging is a potential yet rarely reported approach. Herein, we report the in situ growth of manganese dioxide nanosheets (MnO2) on silica-coated semiconductor quantum dots (QD@SiO2), to prepare a stable and biocompatible fluorescent nanoprobe (QD@SiO2-MnO2) for the selective and sensitive detection of GSH. The modification of QD@SiO2 with MnO2 significantly quenched the fluorescence of CdSe/ZnS QDs, yet the addition of GSH efficiently recovered the fluorescence of the nanoprobe due to the decomposition of MnO2 by GSH. This nanosensor showed a rapid response to GSH with a low detection limit, and high selectivity towards GSH over potential interferences. Furthermore, the MnO2-engineered QDs had good biocompatibility and cellular uptake ability, and were successfully applied for the real-time imaging of intracellular GSH. We envision that semiconductor QD-based probes will stimulate the study of GSH dynamics and facilitate the understanding of GSH-related pathophysiological events.
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