期刊
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 75, 期 -, 页码 221-228出版社
ELSEVIER
DOI: 10.1016/j.msec.2016.12.133
关键词
PMMA; Nano-hydroxyapadte; In vitro bioactivity; Porosity; Mechanical strength and hemocompatibility
资金
- UGC - Rajiv Gandhi National Fellowship [F1-17.1/2013-14/RGNF-2013-14-SC-TAM-44163/(SA-III/Website)]
In this study, we report the preparation of nano-hydroxyapatite (nHAp) incorporated poly(methyl methacrylate) (PMMA) scaffolds by conjugated thermal induced phase separation (TIPS) and wet-chemical approach, which essentially facilitates the enhancement of both mechanical as well as biological properties of the scaffolds. The dissolution of PMMA was accomplished by acetone (Ace scaffold), ethanol-water (E-W scaffold) and isopropanol-water (I-W scaffold) mixtures as solvents. The existence of nHAp in PMMA matrix was investigated systematically. The higher degree of porous architecture was achieved from Ace scaffolds compared to both I-W and E-W scaffolds. On the other hand, the dense porous architecture of the scaffold exhibited superior hardness and compressive strength than that of the Ace and E-W scaffolds. All the fabricated samples demonstrated enhanced in vitro bioactivity with respect to increasing immersion period as a result of flower-like in vitro apatite layer formation. The MTT assay was carried out for 1 day and 3 day culture using Saos-2 osteoblast-like cells, which showed better cell proliferation with increasing culture period owing to the interconnected pore architecture of scaffolds and the rational hemocompatibility as per the ASTM standard F756-00. (C) 2017 Published by Elsevier B.V.
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