期刊
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 75, 期 -, 页码 620-628出版社
ELSEVIER
DOI: 10.1016/j.msec.2017.02.100
关键词
Composite cements; Mesoporous magnesium silicate; Calcium sulfate; Cytocompatibility
资金
- National Natural Science Foundation of China [31271031]
- Major International Joint Research Project between China and Korea [81461148033]
- National Research Foundation of Korea (NRF) [NRF-2014K2A2A7066637]
In this study, composite cements containing mesoporous magnesium silicate (m-MS) and calcium sulfate (CS) were fabricated. The results revealed that the setting time of the m-MS/CS composite cements (m-MSC) slightly prolonged with the increase of m-MS content while the compressive strength suffered a little loss. The doping of m-MS improved the water absorption, drug release (vancomycin) and degradability of the m-MSC in Tris-HCl solution (pH = 7.4). In addition, addition of m-MS facilitated the apatite-mineralization of m-MSC in simulated body fluid (SBF), indicating good bioactivity. For cell cultural experiments, the results revealed that the m-MSC promoted the cells adhesion and proliferation, and improved the alkaline phosphatase (ALP) activity of MC3T3-E1 cells, revealing good cytocompatibility. It could be suggested that the m-MSC might be promising cements biomaterials for bone tissue regeneration. (C) 2017 Published by Elsevier B.V.
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