期刊
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 75, 期 -, 页码 471-477出版社
ELSEVIER
DOI: 10.1016/j.msec.2017.02.088
关键词
Calcium phosphate cement; Tricalcium phosphate; Hydrogel; Star-P(EO-stat-PO)
资金
- Deutsche Forschungsgemeinschaft (DFG) [GB1/20-1, GR3232/3-1]
Natural bone is an organic-inorganic composite of highly ordered collagen fibrils and similar to 60-70% nanocrystalline hydroxyapatite (HA) crystals resulting in a high fracture resistance for various mechanical loading situations. This study aimed to synthesize highly mineralized hydrogels to mimic the mechanical properties of cancellous bone. A six armed star molecule functionalized with isocyanate groups as reactive termini (NCO-sP(EO-stat-PO)) was used to build up a hydrogel matrix, which was then subsequently mineralized with hydroxyapatite nanocrystals following the hydrolysis of incorporated a-tricalcium phosphate particles. The advantage of this dual setting approach in comparison to simply adding unreactive filler particles to the hydrogel was demonstrated to be a strength improvement by the factor of 30. After 1-28 d setting, the mechanical properties of a composite with 30 wt% NCO-sP(EO-stat-PO) such as elasticity (5.3-1.4%), compression strength (11-23 MPa) and E-modulus (211-811 MPa) were found to be similar to the properties of cancellous bone. (C) 2017 Published by Elsevier B.V.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据