期刊
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 73, 期 -, 页码 596-602出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2016.12.106
关键词
Hydroxyapatite; Selenium; Controllable synthesis; Biocompatibility
资金
- National Natural Science Foundation of China [21376190, 21676215, 51578447, 51408453]
- National High Technology Research and Development Program of China [2014AA022108, 2012BA17B02]
- Specialized Research Fund for the Doctoral Program of Higher Education [20136120120022]
- China Postdoctoral Science Foundation [2013M542378, 2014T70933]
- Shaanxi Provincial Postdoctoral Science Special Foundation [2014907]
- Shaanxi Provincial Natural Science Foundation [2016JQ5075]
- Northwest University Science Foundation [YZZ14045]
Hydroxyapatite (HA) is the major inorganic component of natural bone tissue. As an essential trace element, selenium involves in antioxidation and anticancer of human body. So far, ion-doped hydroxyapatites (HAs) are widely investigated owing to their great applications in field of biomaterial, biological labeling. In this paper, series of monodisperse HA doped with SeO32- (SeHA) was successfully synthesized based on the liquid-solid-solution (LSS) strategy. The obtained samples were characterized by transmission electron microscopy (TEM), Xray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR) and energy-dispersive spectrometer (EDS). The results indicated that the SeO32- doping level of the Se/(P + Se) molar ratio of 0-0.4 can be requisitely controlled, and the morphology of SeHA nanoparticles varied from nanorods to nanoneedles with increasing Se/(P + Se) molar ratio. Significantly, the as-synthesized SeHA nanocrystals exhibit a low cytotoxicity for osteoblastic cells, showing exciting potentials for application in artificial scaffold materials inhibiting of tumor growth in bone. (C) 2016 Elsevier B.V. All rights reserved.
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