期刊
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 73, 期 -, 页码 544-551出版社
ELSEVIER
DOI: 10.1016/j.msec.2016.12.066
关键词
Carboxymethyl chitosan; Magnetic nanoparticles; Silver nanoparticles; Antimicrobial activity
Carboxymethyl chitosan (CMCS) was known to have a much better antimicrobial activity than chitosan due to the increased cationic-NW-groups resulted from the intra-and intermolecular interactions between the carboxyl and amino groups. CMCS was grafted onto the surface of silica coated magnetic nanoparticles (MNPs) to obtain magnetically retrievable and deliverable antimicrobial nanoparticles (MNPs@CMCS). The presence of carboxyl ate groups in CMCS not only enhanced antimicrobial activity but also enabled Ag ions chelating ability to induce the in situ formation of Ag nanoparticles (AgNPs). The deposition of AgNPs on the surface of MNPs@CMCS could significantly increase its antimicrobial activity against planktonic cells due to the dual action of CMCS and AgNPs. Due to its high magnetism, the as-prepared MNPs@CMCS-Ag could be efficiently delivered into an existing bio-film under the guidance of an applied magnetic field. Without direct contact, the Ag ions and/or radical oxygen species (ROS) released from the deposited Ag nanopartides could effectively kill the bacteria embedded in the extracellular polymeric substances (EPS) matrix of biofilm. (C) 2016 Elsevier B.V. All rights reserved.
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