期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 76, 期 8, 页码 1447-1458出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-018-2997-3
关键词
Monocytes; TAM; Macrophage; Cancer; Innate and adaptive immunity
资金
- H2020 European Research Council [OxyMO, 308459]
- European Research Council (ERC) [308459] Funding Source: European Research Council (ERC)
Macrophages play an important role in tissue development and homeostasis. They serve as a nexus between adaptive and innate immunity, and employ considerable plasticity. In cancer, they play a pivotal role in chronic inflammation and tumor growth either by directly stimulating the proliferation of cancer cells or by producing angiogenic and lymphangiogenic factors. Although numerous immune cells play an important role in the tumor microenvironment, tumor-associated macrophages (TAMs) are by far the most extensively studied. A better understanding of the role of TAMs in mediating chemo- and radiotherapy resistance and suppressing immunosurveillance has led to numerous strategies targeting TAMs as an anticancer therapy either by targeting them directly or by polarizing TAMs toward a tumoricidal phenotype.
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