期刊
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 72, 期 -, 页码 7-17出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2016.11.020
关键词
Dentin; Remineralization; Poly (amido amine) dendrimer; Bonding agent; Acid challenge; Calcium phosphate nanoparticles
资金
- NIH [R01 DE17974]
- National Natural Science Foundation of China [81670977, 81170958]
- International Science and Technology Cooperation Program of China [2014DFE30180]
- China Scholarship Council [201506240163]
- University of Maryland School of Dentistry bridging fund
- University of Maryland seed grant
The objectives of this study were to develop a novel method to remineralize dentin lesions, and investigate the remineralization effects of poly (amido amine) (PAMAM) dendrimer plus a bonding agent with nanoparticles of amorphous calcium phosphate (NACP) in a cyclic artificial saliva/lactic acid environment for the first time. Dentin lesions were produced via phosphoric acid. Four groups were tested: (1) dentin control, (2) dentin with PAMAM, (3) dentin with NACP bonding agent, and (4) dentin with PAMAM plus NACP bonding agent. Specimens were treated with cyclic artificial saliva/lactic acid. The remineralized dentin was examined using scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), hardness and attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR). NACP bonding agent yielded a dentin shear bond strength similar to commercial controls (Prime & Bond NT, Dentsply; Scotchbond Multi -purpose, 3M) (p > 0.1). Increasing NACP in bonding agent from 0 to 40% did not affect bond strength. NACP bonding agent neutralized the acid and released Ca ions with concentrations of 4 to 20 mmol/L, and P ions of 2 to 9 mmol/L. PAMAM or NACP bonding agent alone achieved slight remineralization. The PAMAM + NACP group achieved the greatest dentin remineralization p < 0.05). At 20 days, PAMAM + NACP increased the hardness of pre-demineralized dentin to reach the normal dentin hardness (p > 0.1). In conclusion, superior remineralization of PAMAM + NACP bonding agent was demonstrated for the first time. PAMAM + NACP bonding agent induced dentin remineralization under acid challenge, when conventional remineralization methods such as PAMAM alone did not work well. The novel PAMAM + NACP bonding agent method is promising to improve the longevity of resin-dentin bonds, inhibit caries, and protect teeth. (C) 2016 Elsevier B.V. All rights reserved.
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