期刊
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 71, 期 -, 页码 431-438出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2016.10.042
关键词
Bioceramic; Nanocomposites; Nanomaterials; Scaffolds
资金
- Isfahan University of Technology, Kimiya Darou Co Ltd. [2896]
- Pennsylvania State University at Harrisburg
In recent decades, bone scaffolds have received a great attention in biomedical applications due to their critical roles in bone tissue regeneration, vascularization, and healing process. One of the main challenges of using scaffolds in bone defects is the mechanical strength mismatch between the implant and surrounding host tissue which causes stress shielding or failure of the implant during the course of treatment. In this paper, space holder method was applied to synthesize diopside/forsterite composite scaffolds with different diopside content. During the sintering process, NaCl, as spacer agent, gradually evaporated from the system and produced desirable pore size in the scaffolds. The results showed that adding 10 wt.% diopside to forsterite can enormously improve the bioactivity, biodegradability, and mechanical properties of the composite scaffolds. The size of crystals and pores of the obtained scaffolds were measured to be in the range 70-100 nm and 100-250 pm, respectively. Composite scaffolds containing 10 wt.% diopside showed similar compressive strength and Young's modulus (4.36 +/- 0.3 and 308.15 +/- 7 MPa, respectively) to that of bone. (C) 2016 Elsevier B.V. All rights reserved.
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