期刊
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 70, 期 -, 页码 969-975出版社
ELSEVIER
DOI: 10.1016/j.msec.2016.04.010
关键词
Hybrid; Chitosan; Cytocompatibility; Sol-gel; Tissue regeneration
资金
- National Natural Science Foundation of China [81572198]
- China Postdoctoral Science Foundation [2015M582443]
- Natural Science Foundation of Guangdong Province, China [2015A030313772]
- Shenzhen Science and Technology Project [JSGG20140519105550503, JCYJ20140414170821200, JCYJ20140414170821164, JCYJ20140414170821160, CXZZ20140813160132596, GJHZ20130412153906739, CXZZ20120614160234842, ZDSY20120614154551201]
Inorganic/organic hybrid scaffolds have great potential for tissue engineering applications due to controllable mechanical properties and tailorable biodegradation. Here, silica/chitosan hybrid scaffolds were fabricated through the sol-gel method with a freeze drying process. 3-Glycidoxypropyl trimethoxysilane (GPTMS) and tetraethylorthosilicate (TEOS) were used as the covalent inorganic/organic coupling agent and the separate inorganic source, respectively. Hybrid scaffolds with various inorganic/organic weight ratios (I/Os) and molar ratios of chitosan and GPTMS (GCs) were examined and compared in this study. FTIR showed that higher GPTMS content resulted in the increased covalent cross-linking of the chitosan and the silica network in hybrids. Compression testing indicated that increasing the GPTMS content greatly improved the compressive strength of scaffold. LIVE/DEAD assay showed that enhanced cytocompatibility was obtained as the silica content increased. Therefore, the results confirmed that the two parameters I/O and GC can largely influence the scaffold performance, which can be used to tailor the hybrid properties. (C) 2016 Elsevier B.V. All rights reserved.
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