期刊
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 76, 期 -, 页码 1316-1327出版社
ELSEVIER
DOI: 10.1016/j.msec.2017.02.056
关键词
Blood brain barrier; Receptor; Ligand; Transport; Target
资金
- National Key Basic Research Project (Project 973) [2014CB541600]
- Fundamental Research Funds for the Central Universities [2015CDJZR, 2016CDJXZ]
- Graduate Scientific Research and Innovation Foundation of Chongqing, China [CYS16015]
The blood brain barrier (BBB) is a physical and biochemical barrier that prevents entry of toxic compounds into brain for preserving homeostasis. However, the BBB also strictly limits influx of most therapeutic agents into the brain. One promising method for overcoming this problem to deliver drugs is receptor mediated transport (RMT) system, which employs the vesicular trafficking machinery to transport substrates across the BBB endothelium in a noninvasive manner. The conjugates of drug or drug-loaded vector linked with appropriate ligands specifically binds to the endogenous targeting receptor on the surface of the endothelial cells. Then drugs could enter the cell body by means of transcytosis and eventual releasing into the brain parenchyma. Over the past 20 years, there have been significant developments of RMT targeting strategies. Here, we will review the recent advance of various promising RMT systems and discuss the capability of these approaches for drug delivery to the brain. (C) 2017 Elsevier B.V. All rights reserved.
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