期刊
COMMUNICATIONS BIOLOGY
卷 2, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s42003-019-0361-2
关键词
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资金
- British Heart Foundation (BHF) [RG/14/5/30893]
- NIHR Biomedical Research Centre at Barts
- Netherlands Organisation for Health Research and Development [ZonMw VIDI 016.136.367]
- NIDDK [K12DK094721]
- Intramural Research Program of the Division of Cancer Epidemiology and Genetics, NCI
- GIANT consortium
- MRC [MC_PC_14089, MC_EX_MR/M009203/1, MR/M009203/1, G9521010] Funding Source: UKRI
There is evidence that lower height is associated with a higher risk of coronary artery disease (CAD) and increased risk of type 2 diabetes (T2D). It is not clear though whether these associations are causal, direct or mediated by other factors. Here we show that one standard deviation higher genetically determined height (similar to 6.5 cm) is causally associated with a 16% decrease in CAD risk (OR = 0.84, 95% CI 0.80-0.87). This causal association remains after performing sensitivity analyses relaxing pleiotropy assumptions. The causal effect of height on CAD risk is reduced by 1-3% after adjustment for potential mediators (lipids, blood pressure, glycaemic traits, body mass index, socio-economic status). In contrast, our data suggest that lung function (measured by forced expiratory volume [FEV1] and forced vital capacity [FVC]) is a mediator of the effect of height on CAD. We observe no direct causal effect of height on the risk of T2D.
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