期刊
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 74, 期 -, 页码 86-93出版社
ELSEVIER
DOI: 10.1016/j.msec.2017.02.004
关键词
Zein; Ethyl cellulose; Water-stability; Drug release; Electrospinning
资金
- Fundamental Research Funds for the Central Universities [JUSRP51621A, JUSRP51505, JUSRP115A04]
- Six talent peaks project in Jiangsu Province [2014-XCL001]
- Industry Academia-Research Joint InnoVation Fund of Jiangsu Province [BY2014023-04]
- Innovation Program for Graduate Education in Jiangsu Province [KYLX16_0795]
A simple and cost-effective way to prepare water-stable zein-based nanofibers for potential drug delivery was presented in this article. Corn protein zein was co-electrospun with hydrophobic ethyl cellulose. Indomethacin, as a model drug, was incorporated in situ into the composite nanofibers. Scanning electron microscopy and element mapping revealed the morphologies of drug-loaded nanofibers and drug distribution, respectively. Fourier transform infrared spectra confirmed the physical blending among the components. Differential scanning calorimetry and X-ray diffraction demonstrated the physical state of drug and polymers in the nanofiber matrix. The composite nanofibers showed a sustained diffusion-controlled release according to the results of in vitro dissolution tests. (C) 2017 Elsevier B.V. All rights reserved.
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