期刊
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 72, 期 -, 页码 359-370出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2016.11.095
关键词
3D collagen; Arothron stellatus; Dermal substitute; Tissue engineering
资金
- Council of Scientific and Industrial Research (CSIR) (India), New Delhi, India [31/6(395)/2014-EMR-I]
The highly interconnected porous dressing material was fabricated with the utilization of novel collagen (COL-SPG) for the efficient healing of the wound. Herein, we report the fabrication of 3D collagen impregnated with bioactive extract (COL-SPG-CPE) to get rid of infection at the wound site. The resultant 3D collagen matrix was characterized physiochemically using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and mechanical property. The dressing substrate possesses the high swelling ability, increase in the porosity, in vitro enzymatic degradability and antibacterial property. The in vitro biocompatibility and fluorescence activity of the collagen scaffold against both NIH 3T3 fibroblast and Human keratinocyte (HaCaT) cell lines assisted in excellent cell adhesion and proliferation over the collagen matrix. Furthermore, the in vivo evaluation of the COL-SPG-CPE 3D sponge exhibited with enhanced collagen synthesis and aids in faster reepithelialization. However, the rate of wound healing was influenced by the expression of vascular endothelial growth factor (VEGF), epidermal growth factor (EGF) and tratisforming growth factor (TGF-beta) growth factors promotes the collagen synthesis, thereby increases the healing efficiency. Based oh the results, COL-SPG-CPE has a potential ability in the remodeling of the wound with the 3D collagen as wound dressing material. (C) 2016 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据