期刊
CUREUS JOURNAL OF MEDICAL SCIENCE
卷 11, 期 3, 页码 -出版社
SPRINGERNATURE
DOI: 10.7759/cureus.4310
关键词
sunitinib; macrocytic anemia; cobalamin; folate; toxicity; renal cell carcinoma; tyrosine kinase inhibitor
Sunitinib is an oral tyrosine kinase inhibitor (TKI) commonly used in the treatment of renal cell carcinoma (RCC). Among a broad range of toxicities, anemia and macrocytosis are common in patients treated with sunitinib. Correlation between sunitinib-associated macrocytosis and cobalamin deficiency has been reported in small case series and retrospective analyses, although others have not found an association. Here, we present a case of transfusion-dependent macrocytic anemia with cobalamin and folate deficiency in a patient with RCC treated with sunitinib.
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