期刊
LAB ON A CHIP
卷 19, 期 7, 页码 1236-1246出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8lc01292j
关键词
-
类别
资金
- Netherlands Center for Multiscale Catalytic Energy Conversion (MCEC), an NWO Gravitation programme - Ministry of Education, Culture and Science of the government of the Netherlands
Temperature control for lab-on-a-chip devices has resulted in the broad applicability of microfluidics to, e.g., polymerase chain reaction (PCR), temperature gradient focusing for electrophoresis, and colloidal particle synthesis. However, currently temperature sensors on microfluidic chips either probe temperatures outside the channel (resistance temperature detector, RTD) or are limited in both the temperature range and sensitivity in the case of organic dyes. In this work, we introduce ratiometric bandshape luminescence thermometry in which thermally coupled levels of Er3+ in NaYF4 nanoparticles are used as a promising method for in situ temperature mapping in microfluidic systems. The results, obtained with three types of microfluidic devices, demonstrate that temperature can be monitored inside a microfluidic channel accurately (0.34 degrees C) up to at least 120 degrees C with a spot size of ca. 1 mm using simple fiber optics. Higher spatial resolution can be realized by combining luminescence thermometry with confocal microscopy, resulting in a spot size of ca. 9 m. Further improvement is anticipated to enhance the spatial resolution and allow for 3D temperature profiling.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据